Cell culture and western blotting studies revealed that aflatoxin B 1 AFB 1 inhibits the biosynthesis of two of the constituent polypeptides of al recognition particle SRP SRP54 and SRP escorts polyribosomes carrying al peptides from free form in the cytosol to the bound form on endoplasmic reticulum ER membrane during protein targeting. The of the experiments presented in this article therefore local red deer escorts us to infer for the first time that aflatoxin B 1 may inhibit vegas milf escorts functioning of SRP as an escort and deplete the ER of polyribosomes for secretory protein synthesis.
As these secretory proteins are important components of the plasma membrane, gap junctions and intercellular matrix, their absence from these locations could disturb cell to cell communication leading to tumorigenesis. Please enable it to take advantage of the complete set of features!
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Inhibition of the biosynthesis of srp polypeptides and secretory proteins by aflatoxin b1 can disrupt protein targeting
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of items displayed: local sex personals seneca oregon 10 15 20 50 Create RSS Cancel. RSS Link Copy. Cite Display options Display options. Singh J, et al. Cell Biochem Funct. PMID: Inefficient targeting to the endoplasmic reticulum by the al recognition particle elicits selective defects in post-ER membrane trafficking.
Lakkaraju AK, et al. Exp Cell Free personal dating. Epub Dec The al sequence of nascent preprolactin interacts with the 54K polypeptide of the al recognition particle. Kurzchalia TV, et al. Targeting proteins to membranes: structure of the al recognition particle.
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Egea PF, et al. Curr Opin Struct Biol. PMID: Review. Advances in the structure and functions of al recognition particle in protein targeting. Dani HM, diamond escort ellesmere port al. J Biol Regul Homeost Agents. See all similar articles.
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Cited by 1 article Lactobacillus rhamnosus strain GG reduces aflatoxin B1 transport, metabolism, and toxicity escorts monmouth county Caco-2 Cells. Gratz S, et al. Appl Environ Microbiol.